Study Identifies Potential Breakthrough in Hair Loss Treatment
Male pattern baldness affects a significant number of men, with about two-thirds experiencing hair loss by age 35 and 85% by age 50. This condition can have negative emotional effects on individuals, leading to decreased self-esteem and fear of aging. However, a recent study published in the journal PNAS suggests a potential breakthrough in treating baldness.
The study reveals that hair follicles become stiff with age, contributing to hair loss. Researchers discovered that increasing the production of a specific type of microRNA , known as miR-205, could soften the hair follicle cells, promoting hair growth and regeneration. MicroRNAs are tiny RNA particles present in all living cells that act as messengers, regulating protein production.
Dr. Michele Green, a cosmetic dermatologist, explains that hair follicles contain various stem cells responsible for hair growth regulation. The study's findings indicate that miR-205 could stimulate hair growth by softening the stem cells in hair follicles. The effect was observed in both young and old mice, with increased hair growth evident within ten days.
Current treatments for baldness include minoxidil , finasteride , laser light therapy , and platelet-rich plasma (PRP). These treatments work through different mechanisms such as stimulating circulation, reversing follicle miniaturization, or inhibiting the hormone responsible for hair loss (DHT). However, the potential treatment based on miR-205 would operate through a distinct mechanism.
While the study's results are promising, Dr. Ken L. Williams, Jr., a hair surgeon, cautions that it is too early to determine the practical application of these findings. Further research is necessary to ascertain whether this approach can be successfully translated to human treatments.
Dr. Green adds that the study was conducted on genetically engineered mice, underscoring the need for additional investigations to assess the efficacy in humans. Nonetheless, she anticipates that researchers might explore topical treatments to deliver microRNA directly to the skin.
In conclusion, while the study offers hope for the future of hair loss treatment , more research is required before determining its viability. If successful, the development of a new treatment based on miR-205 could revolutionize hair restoration. However, it remains uncertain whether miR-205 would be administered through transdermal injections or oral tablets.